Mechanisms of neuroprotection during ischemic preconditioning: Lessons from anoxic tolerance
نویسندگان
چکیده
منابع مشابه
Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
The molecular mechanisms underlying preconditioning (PC), a powerful endogenous neuroprotective phenomenon, remain to be fully elucidated. Once identified, these endogenous mechanisms could be manipulated for therapeutic gain. We investigated whether lymphocyte cell kinase (Lck), a member of the Src kinases family, mediates PC. We used both in vitro primary cortical neurons and in vivo mouse ce...
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In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential applications of cerebral preconditioning and ischemic tolerance. Articles related t...
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Ischemic preconditioning represents an important adaptation mechanism of CNS, which results in its increased tolerance to the lethal cerebral ischemia. The molecular mechanisms responsible for the induction and maintenance of ischemic tolerance in the brain are complex and not yet completely clarified. In the last 10 years, great attention has been devoted to unravel the intracellular pathways ...
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Background Brief episodes of ischemia render the heart more resistant to subsequent ischemia; this phenomenon has been called ischemic preconditioning. In some animal species, myocardial preconditioning appears to be due to activation of ATP-sensitive K' (KATP) channels. The role played by KATP channels in preconditioning in humans remains unknown. The aim of this study was to establish whether...
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Background and Purpose—The importance of bioactive lipid signaling under physiological and pathophysiological conditions is progressively becoming recognized. The disparate distribution of sphingosine kinase (SphK) isoform activity in normal and ischemic brain, particularly the large excess of SphK2 in cerebral microvascular endothelial cells, suggests potentially unique celland region-specific...
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ژورنال
عنوان ژورنال: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
سال: 2007
ISSN: 1095-6433
DOI: 10.1016/j.cbpa.2006.08.032